Genetic Disorders of the Glomerular Filtration Barrier
نویسندگان
چکیده
منابع مشابه
The Glomerular Filtration Barrier: Components and Crosstalk
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules. Its integrity is maintained by physicochemical and signalling interplay among its three core constituents-the glomerular endothelial cell, the basement membrane and visceral epithelial...
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Severe defects in the glomerular filtration barrier result in nephrotic syndrome, which is characterized by massive proteinuria. The podocyte, a specialized epithelial cell with interdigitating foot processes separated by a slit diaphragm, plays a vital role in regulating the passage of proteins from the capillary lumen to Bowman's space. Recent findings suggest a critical role for endocytosis ...
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BACKGROUND Chronic kidney disease (CKD) is associated with substantial burden and is a strong risk factor for cardiovascular disease. However, data on the relationship between CKD and stroke are few and are limited by unreliable or inadequate assessment of renal function. OBJECTIVE To properly assess the relationship between renal insufficiency and stroke in stroke survivors in the United Sta...
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The anionic charge barrier and the endothelial and epithelial pore sizes on the glomerular filtration barrier (GFB) were examined in white leghorn chickens (Gallus gallus). Ruthenium red was used to stain anionic charge sites on the GFB. The tissue was treated by normal dehydration and freeze substitution dehydration for transmission electron microscopy (TEM). In addition, the basal lamina was ...
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The mechanisms by which the kidney retains albumin and larger proteins in the circulation while excreting smaller solutes remain enigmatic despite intense investigation. Although the controversy largely plays out in academic journals, the problem is anything but academic, because the health of millions of adults hinges on effective treatment of proteinuric CKD. Proteinuria is associated with ca...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2020
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.11440919